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Caspase


Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation.These forms of cell death are important for protecting an organism from stress signals and pathogenic attack. These are signalling molecules that allow recruitment of immune cells to an infected cell or tissue. There are other identified roles of caspases such as cell proliferation, tumour suppression, cell differentiation, neural development and axon guidance and ageing.
  • Z-DEVD-FMK EY0681

    Z-DEVD-FMK是Caspase-3的特异不可逆抑制剂,对Caspase-6、-7、-8和Caspase-10也有抑制作用。

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  • Ac-YVAD-CMK EY2016

    Ac-Tyr-Val-Ala-Asp-CMK is a cell-permeable and irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5.

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  • Caspase-1 inhibitor-I EY2017

    A cell-permeable inhibitor of caspase-1, caspase-4, and caspase-5.

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  • Tasisulam EY1593

    Tasisulam是一种抗肿瘤剂,是通过内源途径导致细胞凋亡的诱导物。

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  • PAC-1 EY1519

    PAC-1是首个Caspase活化化合物,EC50值为0.22uM,能增强procaspase-3活性并诱导多种癌细胞和小鼠肿瘤模型凋亡。

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  • Z-DEVD-FMK EY0681

    Z-DEVD-FMK是Caspase-3的特异不可逆抑制剂,对Caspase-6、-7、-8和Caspase-10也有抑制作用。

    More
  • Ac-YVAD-CMK EY2016

    Ac-Tyr-Val-Ala-Asp-CMK is a cell-permeable and irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5.

    More
  • Caspase-1 inhibitor-I EY2017

    A cell-permeable inhibitor of caspase-1, caspase-4, and caspase-5.

    More
  • Tasisulam EY1593

    Tasisulam是一种抗肿瘤剂,是通过内源途径导致细胞凋亡的诱导物。

    More
  • PAC-1 EY1519

    PAC-1是首个Caspase活化化合物,EC50值为0.22uM,能增强procaspase-3活性并诱导多种癌细胞和小鼠肿瘤模型凋亡。

    More
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